When an image-conscious wild child takes a strange new drug at a party, she undergoes a shocking transformation. Desperate to reverse the effects of the drug, she is horrified to discover that she has become the key to saving the human race.

　　When an image-conscious wild child takes a strange new drug at a party, she undergoes a shocking transformation. Desperate to reverse the effects of the drug, she is horrified to discover that she has become the key to saving the human race.

　　長眠於地球深處的巨大怪獸逐一甦醒，全球陷入天崩地裂的毀滅危機。人類存亡的最終關鍵，掌握在一名怪獸專家的手中……

故事是发生在第一集的七年后，上一集里的主人公安尼的妹妹萨曼莎和她最好的朋友科利现在都已经18岁了，他们正计划着一次前往LA的公路旅行。但在路上，他们看到了奇异的景象......

CBS续订疑犯追踪 第五季。本季只有13集，很可能为最终季。并且将移到冬歇季播出。