一位年轻女医生的私生活陷入困境后，为寻求新的开始，接手柏林最艰难、最混乱医院的急诊室。面对员工的抵触和破旧系统的同时，她必须团结这支特立独行的团队来挽救生命。

Milan, 2030; where only eight years earlier the independent global spy agency Citadel was wiped out by Manticore, the powerful enemy syndicate that manipulates the world from the shadows. Since then, Diana Cavalieri (who is an undercover Citadel agent) is alone, trapped behind enemy lines as a mole in Manticore. When Diana finally sees a way out and the chance to disappear fore...

　　Milan, 2030; where only eight years earlier the independent global spy agency Citadel was wiped out by Manticore, the powerful enemy syndicate that manipulates the world from the shadows. Since then, Diana Cavalieri (who is an undercover Citadel agent) is alone, trapped behind enemy lines as a mole in Manticore. When Diana finally sees a way out and the chance to disappear forever, her only option is to trust the most unexpected ally, Edo Zani, heir of Manticore Italy, son to the head of the evil syndicate's Italian unit; who just so happens to be vying for Manticore's leadership against other European families.

在柏林工作的年轻人保罗·沃伊特（马提亚斯·施维赫夫 Matthias Schweighöfer 饰）有一份特殊的职业——专门帮已经不想爱的两个人分手。作为专业的分手专家，公司经常派遣他去全国各地了结感情纠葛。虽然保罗并不热爱自己的职业工作，但只要在两年内成功拆散1000对情侣，他就能得到晋升。于是保罗还是勉为其难地继续着这份“分手”工作。对于情侣分手时的各种过激反应，保罗早就习以为常了。但这次保罗要面对的客户可不那么容易解决，一位性情敏感又行为古怪的男子托托·库尔曼（米兰·佩斯彻尔 Milan Peschel 饰）让保罗简直濒临崩溃的边缘。阴差阳错的，陷入一片混乱中的保罗竟意想不到的遇见了他的真爱娜塔莉（凯瑟琳·德·林恩 Catherine de Léan 饰），从此保罗对于生活和爱情也有了新的认识。

约亨沃尔特是德国银行的一名资深投资银行家，与其助手汤姆·斯莱扎克刚刚完成一笔大单。庆功会上约亨却突然跳楼自杀。全球范围内有多起银行家自杀的案例的情况下，外界纷纷猜测约亨的自杀原因，甚至有人怀疑是他杀。约亨的妻子对银行推卸责任的说法很不满，称约亨自杀前留下一封遗书，其中有涉及约亨真实死亡原因的银行保单。汤姆对其突然死亡也表示怀疑，天台拍摄到跳楼过程的摄像头也被移走。到底是自杀还是谋杀。