Blood Sisters tells the story of two friends Sarah (Ini Dima-Okojie) and Kemi (Nancy Isime). Sarah is engaged to her dream man, Kola (Deyemi Okanlawon.) However, their seemingly idyllic union has a dark side.

　　富有的新郎在订婚派对上失踪后，好闺蜜莎拉和凯蜜因为二人之间的一个危险秘密而不得不踏上逃亡之路。