In Notes of Autumn, Ellie (Williams) is a fun-loving, classically trained pianist living in the city who gave up on her passion long ago. She now works for a hotel and always seems to be getting things wrong when musical inspiration strikes. Her best friend, Leo (Macfarlane), lives in the rustic outskirts of British Columbia. He’s a famous author with writer’s block who can’t finish another installment in his highly popular book series. They both need a change of scenery as the chilly days of autumn settle in and decide to swap places, ending up completely lost in new surroundings.　　Ellie gets tangled up in helping Leo’s neighbor, Sam (Rosner), put together a musical performance for a local fundraiser and comes to terms with why she quit music years ago. Meanwhile, Leo strikes up a friendship with Ellie’s good friend Matt (Porte) and opens himself up to writing something different that really inspires him. Their newfound friendships turn into something far more meaningful. As both Ellie and Leo take part in the joys of the autumn season, they also discover their hearts belong somewhere very different than they ever thought possible.

　　克洛伊去教堂后，立刻被牧师卡莱布吸引。她爱上了他，却发现他已婚——和另外两个女人。当其中一位妻子神秘失踪时，克洛伊担心自己可能是下一个受害者。

记录了一个家庭为保持团结而充满希望的战斗，因为个人恶魔和破坏性秘密威胁要将他们撕裂。

2008年经济危机爆发时，华尔街一家投资银行的分析师皮特·苏利文（扎克瑞·昆图 Zachary Quinto 饰）发现公司的财产评估有着巨大的漏洞，即将导致银行的破产。公司高层连夜开会希望挽救公司。富有经验的股票经纪人山姆·罗吉斯（凯文·史派西 Kevin Spacey 饰）、证券经纪人贾德·科恩（西蒙·贝克 Simon Baker 饰）、金融危机分析师萨拉·罗伯特森（黛米·摩尔 Demi Moore 饰）、老总约翰·图尔德（杰瑞米·艾恩斯 Jeremy Irons 饰）都来到了会议现场。会议决定，银行要以极低的价格抛售债权和股票。但此一举虽能使银行能得到暂时的安稳，但却会引发一系列连锁反应.......

泰德（乔什·拉德诺 Josh Radnor 饰）、马修（杰森·席格尔 Jason Segel 饰）和巴尼（尼尔·帕特里克·哈里斯 Neil Patrick Harris 饰）是三个好友，其中只有马修拥有一份稳定爱情——他很快要和幼儿园老师莉莉（艾丽森·汉妮根 Alyson Hannigan 饰）结婚了。而巴尼是个典型花花公子，对他来说，安定下来是不可能的。泰德倒是很想找到所爱，进入正常婚姻生活，也终于在酒吧遇到了心中的女神——美丽女主播罗宾（寇碧·史莫德斯 Cobie Smulders），岂料第一次约会，泰德就心急表白，将女神吓到了。为了解决泰德的爱情困扰，几位损友争相为他出主意，罗宾也慢慢进入他们的好友圈…… 　　本剧最特别之处在于以泰德未来小孩的口吻倒叙，但老爸可以确定的情况下，到底谁是老妈？始终是全剧最大悬念。