故事的主角是一只名叫白牙（尼克·奥弗曼 Nick Offerman 配音）的狼，它自幼生长在弱肉强食的世界之中，早已经习惯了其中的尔虞我诈。长大之后，母亲将白牙带回了主人身边——一位善良强壮的印第安人，就这样，白牙有了一份拉雪橇的工作，日子在平静中一天一天的过去了。 　　然而，拮据的经济让主人不得不将白牙卖给了一个名为史密斯的男人，史密斯满肚子坏水，丝毫没有仁爱之心，只想着怎样榨取利益，在史密斯的调教之下，白牙成为了一匹斗狼，用自己的鲜血为史密斯换取金钱。幸运的是，白牙很快就遇见了自己的新主人斯科特，斯科特用爱和关怀渐渐治愈了白牙受伤的心灵。

Beginning just after the bloody Sioux victory over General Custer at Little Big Horn, Bury My Heart at Wounded Knee intertwines the perspectives of three characters Charles Eastman (Beach), né Ohiyesa, a young, Dartmouth-educated, Sioux doctor held up as living proof of the alleged success of assimilation; Sitting Bull (Schellenberg), the proud Lakota chief who refuses to submit to U.S. government policies designed to strip his people of their identity, their dignity and their sacred land – the gold-laden Black Hills of the Dakotas; and Senator Henry Dawes (Quinn), who was one of the architects of the government policy on Indian affairs. While Eastman and patrician schoolteacher Elaine Goodale (Paquin) work to improve life for the Indians on the reservation, Senator Dawes lobbies President Grant (Thompson) for more humane treatment, opposing the bellicose stance of General William Tecumseh Sherman (Feore). Hope rises for the Indians in the form of the prophet Wovoka (Studi) and the Ghost Dance – a messianic movement that promises an end of their suffering under the white man. This hope is obliterated after the assassination of Sitting Bull and the massacre of hundreds of Indian men, women and children by the 7th Cavalry at Wounded Knee Creek on Dec. 29, 1890. Written by HBO Films

凯奇饰演前神枪手演科尔顿·布里格斯，现在经营着一家杂货店，和家人一起平静地生活。当一帮歹徒残忍地杀害了他的妻子，布里格斯回到家，发现他的世界在燃烧。他掏出手枪，和一个意想不到的人——他12岁的女儿组队一起寻求复仇。