Murdoch is in Bristol, England, with no memory of who he is and two gunmen chasing him through the streets. With the help of a local pub Landlady he starts to piece together an assassination plot. In Toronto Detective Hamish Sloack is assigned to help find the missing Murdoch.
In an attempt to rectify their criminal past, a once successful Hollywood starlet, turn prostitute, and a petty, misogynistic thief, set out together to solve a high profile child abduction case in San Francisco.