一对兄弟在他们的庄园附近发现了一具残缺不全的尸体，于是召集当地人一起调查。他们很快了解到，村子里发生的怪事是由一个恶灵引起的，这个灵魂进入了一个当地人的体内，他们等待着通过适当的程序驱逐他体内溃烂的恶魔。主角们不得不与迫在眉睫的危险赛跑，试图摆脱恶灵无情的魔爪。

加菲猫是一只把所有的时间都花在吃东西、看电视、睡觉上面的一只大胖猫。它的主人则是一个懒散的年轻人，他还拥有一只整天只知道吐舌头和追汽车的小狗——欧第。当然，欧第就成了加菲每天玩弄的对象。这一系列的动画片就是围绕着一只肥猫、一条傻狗和一个整天迷迷糊糊的主人展开的。

Skyway Robbery Jon, Garfield and Odie are passengers on a rickety broken-down plane flown by Al G. Swindler, who bails out and leaves them to fly the plane. The Bunny Rabbits is Coming! Orson and the others receive a moxia.cc telegram that says only 'The bunny rabbits is coming'. Close Encounters of the Garfield Kind John, Garfield and Odie encounter a cute little alien whose reasons for coming to earth are more sinister than he leads them to believe.

《加菲猫和他的朋友们第二季》是一部由Jeff HallTom Ray、Ron Myrick执导，Lorenzo Music等主演的动画片，1989年9月17日在美国首播。

In honor to celebrate the 15th anniversary of Garfield, CBS aired the sixth season in 1993. For this season, the titles changed at the beginning. Instead of showing clips from only the first two seasons, which is what happened for the last three seasons, the titles included more clips from the fifth season, plus some from this season and one from a second season episode Health Feud, but still retaining a large amount of the original clips. However, the theme tune remained the same. Episodes 90–96 are available on the Garfield and Friends Volume 4 DVD set. Episodes 97–105 are available on Garfield and Friends Volume 5 DVD set.